Nattokinase (Enzyme from natto (fermented soybeans). Contains soy.)

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About Nattokinase

Plant: Enzyme from natto (fermented soybeans). Contains soy.

A fibrin-dissolving enzyme, used for biofilm and fibrin nests. A documented alternative to Lumbrokinase, generally considered somewhat less potent but useful if Lumbrokinase is not tolerated or available.

Reference dosing

DosingAllergy Research Group label: 1 softgel (100 mg NSK-SD, 2,000 FU) twice daily with 8 to 10 oz of water, or as directed by your practitioner. Take away from food, as with other enzymes. The Recovery guide also lists 20,000 FU twice daily as a higher-dose option: agree any higher dose with your prescriber.

Label warnings: use only under medical supervision if you take anticoagulant drugs, and do not use in any condition associated with bleeding. Ask a practitioner first if you are pregnant, breastfeeding, have a health condition or take any medication. Dosed as capsules, not as a tincture.

These are figures from the sources used on this site. They are not a prescription. Follow the product label and your prescriber.

Safety and cautions

Contraindications: Use only under medical supervision if you take anticoagulant drugs, and do not use in any condition associated with bleeding (Allergy Research Group label). Ask a practitioner first if you are pregnant or lactating, have a health condition or take any medication. Made from fermented soybeans, so it contains soy. The product page lists no other drug interactions, which means none are documented there, not that none exist: check with your prescriber or pharmacist.

Herbs can interact with prescription medicines and other supplements. Check with your prescriber or pharmacist first, and do not use herbs in pregnancy or while breastfeeding unless a doctor agrees.

Information last checked: 6 November 2026.

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