LYME TOOLS: SICK OF THIS SHIT

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Contraindications



Contraindications Reference

Covers herbs and prescription drugs commonly used across Borrelia, Bartonella and Babesia protocols. Items marked ⚠ require a specific test before starting — check those first.

Used forBartonella, Babesia
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsMust not be combined with antidepressant medication — this includes duloxetine and mirtazapine. Excluded outright from the Bartonella protocol on this basis.
Used forBorrelia
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsCan trigger a skin rash in some users; discontinue if this occurs. Cryptolepis or Banderol are documented substitutes with comparable effect.
Used forBabesia
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsUse caution with existing cardiac issues. Isolated artemisinin carries a resistance risk with continuous use — periodic breaks are required (Ross cycles it 3 days on, 11 days off).
Used forBorrelia, Bartonella, Babesia
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsMust not be combined with antidepressant medication — this includes duloxetine and mirtazapine. Excluded outright from the Borrelia and Bartonella protocols on this basis.
Used forBorrelia
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsContraindicated in late-stage chronic Lyme disease specifically — stimulates already-elevated Th1 immune pathways and can aggravate symptoms. Only appropriate for pre-exposure, early localized, or early disseminated stages.
Used forBabesia
DescriptionThe antimalarial component of Malarone; almost always prescribed as the combination product rather than alone for Babesia.
ContraindicationsSame core cautions as Malarone. Absorption is significantly reduced without food — always taken with a meal.
Used forBorrelia, Bartonella
DescriptionA macrolide antibiotic, generally with fewer drug interactions than clarithromycin.
ContraindicationsCarries a QT-prolongation risk — caution with existing arrhythmia or other QT-prolonging drugs.
Used forBorrelia
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsExcess doses can induce nausea and vomiting — a sign the dose should be reduced.
Used forBorrelia
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsAvoid with blood-thinning or immunosuppressive medication, and discontinue 10 days before surgery. Use caution with existing low blood pressure. Deactivated by stomach acid blockers/antacids — substitute Ashwagandha or Cordyceps if these are needed.
Used forBorrelia
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsA strong synergist that can raise blood concentrations of co-administered medications — consult a doctor before combining with antibiotics, steroids, blood pressure medication, or diabetes medication. This includes several drugs on this page (Doxycycline, Rifampin, Clarithromycin).
Used forBartonella, Babesia, Borrelia
DescriptionA macrolide antibiotic used across Bartonella, Babesia and Borrelia prescription protocols.
ContraindicationsCarries a QT-prolongation risk — use caution combining with other QT-prolonging drugs. Significant CYP3A4 interactions with many medications. A documented, sometimes fatal interaction exists with colchicine in patients with renal or hepatic impairment.
Used forBabesia
DescriptionUsed in combination with Quinine sulfate as an alternative Babesia regimen.
ContraindicationsCarries a notable risk of C. difficile-associated colitis — severe or persistent diarrhea during or after treatment warrants prompt medical attention.
Used forBorrelia, Bartonella
DescriptionUsed for persister-phase Borrelia (Horowitz’s Double-Dose Dapsone Combination Therapy) and in resistant Bartonella protocols.
ContraindicationsRequires G6PD testing before starting — contraindicated in G6PD deficiency due to hemolytic anemia risk. Also carries a methemoglobinemia risk; use caution combining with other oxidizing drugs.
⚠ Testing Required G6PD test required before starting.
Used forBorrelia
DescriptionA tetracycline antibiotic and the standard first-line prescription option for Borrelia.
ContraindicationsNot for children under 8 or during pregnancy/breastfeeding (permanent teeth staining risk). Avoid taking at the same time as calcium supplements or dairy — chelation significantly reduces absorption; separate by at least 2 hours. Causes photosensitivity — sun protection is required while on it. Avoid combining with isotretinoin (intracranial hypertension risk).
Used forGeneral reference / cross-referenced medication
DescriptionAn SNRI antidepressant — included here as a cross-reference point, since it appears frequently as a background medication and interacts with several items on this page.
ContraindicationsContraindicated with MAOIs (including within 14 days of stopping either drug). Carries a serotonin syndrome risk when combined with Methylene Blue (see that entry). Several herbs in Buhner’s protocol — Ashwagandha and Alchornea cordifolia specifically — are documented as contraindicated with antidepressants generally; duloxetine falls under that caution.
Used forBartonella
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsAvoid if hypersensitive to caffeine.
Used forBartonella
DescriptionUsed in combination with Methylene Blue for Bartonella-related brain fog, and separately for yeast/Candida overgrowth.
ContraindicationsA CYP3A4 and CYP2C9 inhibitor with many drug interactions. Use caution combining with other QT-prolonging drugs. Extended use warrants liver function monitoring.
Used forBorrelia
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsCirculatory disease patients should consult a physician before use.
Used forBorrelia, Bartonella
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsLowers blood pressure — those with hypotensive tendencies should monitor status or use an alternative.
Used forBorrelia
DescriptionUsed as an alternative to rifampin/tinidazole for cyst-form Borrelia.
ContraindicationsA strong CYP3A4 inhibitor — significantly raises blood levels of many other medications (certain statins, some calcium channel blockers, immunosuppressants). Review all current prescriptions with a doctor or pharmacist before combining.
Used forBorrelia
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsLimited to one month of continuous use. Increases bile flow — contraindicated in bile duct obstruction or active liver disease, and must not be combined with other medication, especially paracetamol.
Used forBartonella
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsMust be avoided by anyone with pre-existing pathologically low blood pressure.
Used forBorrelia, Bartonella
DescriptionSometimes added to more aggressive combination protocols.
ContraindicationsLong-term use carries a retinal toxicity risk — periodic eye exams are required. Use caution in G6PD deficiency (milder hemolysis risk than dapsone or tafenoquine, but still relevant). Carries a QT-prolongation risk.
Used forBartonella
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsLimited to 3 consecutive weeks before a one-week break — prolonged high-dose use can overtax the kidneys.
Used forBartonella
DescriptionAn alternative to Fluconazole for Bartonella-related brain fog protocols.
ContraindicationsContraindicated with numerous CYP3A4-metabolized drugs (including certain statins). Not for use in anyone with a history of ventricular dysfunction or heart failure. Requires an acidic stomach environment for absorption — avoid combining with acid-reducing medication (e.g. PPIs) at the same time.
Used forBorrelia, Bartonella, Babesia
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsAvoid with blood-thinning medication (stop 10 days before surgery) or existing high estrogen levels. Can cause temporary loss of taste in roughly 1% of people.
Used forBabesia
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsLowers blood pressure (unlike Siberian Ginseng) — use caution with existing hypotension.
Used forBartonella, Babesia
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsContraindicated in severe hypertension; prolonged uncycled use can itself raise blood pressure. Must not be used with an active viral infection, particularly herpes — it can intensify viral symptoms.
Used forBabesia
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsCompletely contraindicated in hypertension, hypokalemia, hypernatremia and low testosterone. Not for continuous use beyond 4–6 weeks.
Used forBabesia
DescriptionCombination antimalarial; the standard first-line prescription option for Babesia.
ContraindicationsDo not combine with rifampin or rifabutin — they lower atovaquone blood levels and reduce effectiveness. Use caution in severe renal impairment (creatinine clearance under 30ml/min), due to proguanil accumulation.
Used forBartonella
DescriptionUsed in Bartonella protocols targeting brain fog, alongside Fluconazole or Itraconazole.
ContraindicationsRequires G6PD testing before starting — hemolysis risk in G6PD deficiency. Contraindicated with SSRIs, SNRIs, MAOIs and tricyclic antidepressants — inhibits monoamine oxidase-A and can cause serotonin syndrome, which has been fatal in reported cases. This specifically includes duloxetine and mirtazapine-class antidepressants; an antidepressant washout period (typically at least 5 days) is required beforehand if switching from an SNRI/SSRI.
⚠ Testing Required G6PD test required before starting.
Used forGeneral reference / cross-referenced medication
DescriptionAn atypical antidepressant — included here as a cross-reference point for the same reason as Duloxetine.
ContraindicationsGenerally carries a lower serotonin syndrome risk than SNRIs/SSRIs, but is sedating — use caution combining with other sedating herbs (Valerian/Amantilla, Melatonin) due to additive drowsiness. Falls under the same general antidepressant caution flagged for Ashwagandha and Alchornea cordifolia.
Used forGeneral reference / cross-referenced medication
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsUse caution with asthma, bleeding disorders, active ulcers, respiratory failure, or specific methylation impairments.
Used forBabesia, Bartonella
DescriptionAn antifungal used for yeast/Candida overgrowth support during antibiotic treatment.
ContraindicationsMinimal systemic absorption and few significant drug interactions — one of the better-tolerated antifungal options to combine with other treatment.
Used forBartonella
DescriptionUsed in resistant Bartonella protocols, typically combined with other antibiotics.
ContraindicationsCarries a hepatotoxicity risk — liver function monitoring is required. Avoid in acute gout, since it raises uric acid levels.
Used forBabesia
DescriptionUsed in combination with Clindamycin as an alternative Babesia regimen.
ContraindicationsCarries a QT-prolongation risk — avoid combining with other QT-prolonging drugs. Can cause cinchonism at higher doses (tinnitus, headache, visual disturbance). Use caution in G6PD deficiency (milder hemolysis risk).
Used forBartonella
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsA potent blood coagulant — never combine with anticoagulant or coagulant medication.
Used forBartonella
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsCan cause jitters or over-stimulation in some people — best avoided close to bedtime until tolerance is confirmed.
Used forBartonella, Babesia, Borrelia
DescriptionUsed as an adjunct for Bartonella and Babesia, and for cyst-form Borrelia.
ContraindicationsA major CYP450 enzyme inducer — reduces the effectiveness of many other drugs, including hormonal contraceptives and warfarin. Do not combine with Malarone/atovaquone (lowers atovaquone levels). Harmlessly discolors urine, tears and sweat orange. Periodic liver function monitoring is recommended.
Used forBabesia
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsNot for use in severe hypertension, organic heart disorders, acute nervous hyperexcitability, or severe insomnia.
Used forBartonella, Babesia
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsAvoid entirely with existing heart problems (cardiac issues are a hard contraindication in the underlying data). Reduce the dose or discontinue if a headache occurs — a documented dose-sensitivity signal repeated across the Babesia and Bartonella protocols.
Used forBorrelia, Bartonella
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsContraindicated with pharmaceutical calcium channel blockers, beta-blockers, digoxin, antiarrhythmic drugs, AV heart block, and existing low blood pressure.
Used forBabesia
DescriptionA newer antimalarial sometimes used off-label for Babesia, related to primaquine.
ContraindicationsQuantitative G6PD testing is mandatory before starting — contraindicated in G6PD deficiency or unknown G6PD status (hemolytic anemia risk). Also contraindicated in pregnancy, in breastfeeding when the infant’s G6PD status is unknown or deficient, and in anyone with a history of psychosis.
⚠ Testing Required Quantitative G6PD test is mandatory before starting — this is a hard contraindication, not just a caution.
Used forBorrelia
DescriptionUsed specifically to target the cyst form of Borrelia.
ContraindicationsAvoid alcohol during treatment and for 3 days after — causes a disulfiram-like reaction (nausea, vomiting, flushing). Avoid in the first trimester of pregnancy. Potentiates warfarin’s effect.
Used forBorrelia
DescriptionSee the full Herb Database page for plant name, tincture dosing, and general description.
ContraindicationsNever combine with 5-HTP — both regulate the same serotonin pathway; combining them is redundant, not additive.

This reference is for informational purposes only and is not a substitute for advice from your prescribing physician or LLMD. Always disclose your full current medication and supplement list to every provider involved in your care — many of the interactions above only become relevant when combined with something not listed here.