Safety and cautions

Contraindications: Do not combine with blood thinners (warfarin, DOACs) or antiplatelet drugs unless your doctor agrees and is monitoring you. Avoid with active bleeding, bleeding disorders, a recent haemorrhagic stroke, severe liver disease, an active stomach ulcer or uncontrolled high blood pressure. Avoid in pregnancy, when trying to conceive and when breastfeeding. Stop and get medical help for new bruising, nosebleeds, bleeding gums, black stools, heavy periods or severe headache. Tell your surgical or dental team: a safety guide says most clinicians stop it about 5 to 7 days before procedures. Other proteolytic enzymes (Nattokinase, Serrapeptase) and high-dose fish oil add to the same effect. Long-term safety is uncertain. (Source: a consumer safety guide, not a regulator: confirm with your prescriber.) Always check with your prescriber or pharmacist, especially if you take blood thinners or other regular medicines.

Herbs can interact with prescription medicines and other supplements. Check with your prescriber or pharmacist first, and do not use herbs in pregnancy or while breastfeeding unless a doctor agrees.

Information last checked: 6 November 2026.